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Wir freuen uns auf deine vollständige Bewerbung als PDF-Datei per E-Mail an: humanresources@microcoat.de

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Deine Bewerbung hat uns überzeugt? Dann freuen wir uns auf ein persönliches Vorstellungsgespräch mit dir.

Werde Teil des Teams

Es passt für dich und für uns? Herzlich Willkommen! Dein Team freut sich auf dich.

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General chapter on the rFC test adopted by the European Pharmacopoeia Commission

General chapter on the rFC test adopted by the European Pharmacopoeia Commission

MORE EVENTS
  • 04Mai

    Geschützt: ECA Monocyte Activation Test (MAT)

    Read More →
  • 28Apr

    Geschützt: ECA Low Endotoxin Recovery/Masking

    Read More →
  • 03Feb

    Meet us at the Pharmaceutical Microbiology East Coast conference – Boston, USA

    Read More →
  • 25Nov

    Low Endotoxin Recovery/Masking Training Course Munich/Bernried, GERMANY

    Read More →
  • 25Nov

    2nd Monocyte-Activation-Test proficiency test program, 13./14. Februar 2020

    Read More →
  • 21Okt

    Meet us at the PharmaLab 2019 Düsseldorf/Neuss, Germany

    Read More →
  • 23Sep

    Mikrobiologie-Konferenz, 01./02. Oktober 2019 – Mannheim

    Read More →
  • 18Sep

    2019 bioxchange workshop, Philadelphia PA | Philadelphia Downtown Hotel

    Read More →
  • 13Mai

    Meet us at the A3P, Lyon (5. – 6. June 2019)

    Read More →
  • 25Apr

    Meet us at the Workshop „Bioindicators“, Barcelona (07. May 2019)

    Read More →
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New Publication about Bacterial Endotoxin Testing available

New Publication about Bacterial Endotoxin Testing available

Comparison of LAL and rFC Assays – Participation in a Proficiency Test Program between 2014 and 2019

You can find more about the article here:

https://www.mdpi.com/2076-2607/8/3/418

MORE EVENTS
  • 04Mai

    Geschützt: ECA Monocyte Activation Test (MAT)

    Read More →
  • 28Apr

    Geschützt: ECA Low Endotoxin Recovery/Masking

    Read More →
  • 03Feb

    Meet us at the Pharmaceutical Microbiology East Coast conference – Boston, USA

    Read More →
  • 25Nov

    Low Endotoxin Recovery/Masking Training Course Munich/Bernried, GERMANY

    Read More →
  • 25Nov

    2nd Monocyte-Activation-Test proficiency test program, 13./14. Februar 2020

    Read More →
  • 21Okt

    Meet us at the PharmaLab 2019 Düsseldorf/Neuss, Germany

    Read More →
  • 23Sep

    Mikrobiologie-Konferenz, 01./02. Oktober 2019 – Mannheim

    Read More →
  • 18Sep

    2019 bioxchange workshop, Philadelphia PA | Philadelphia Downtown Hotel

    Read More →
  • 13Mai

    Meet us at the A3P, Lyon (5. – 6. June 2019)

    Read More →
  • 25Apr

    Meet us at the Workshop „Bioindicators“, Barcelona (07. May 2019)

    Read More →
READ MORE

Microcoat announces the 3nd Monocyte-Activation Test Proficiency Test Program

Microcoat announces the 3nd Monocyte-Activation Test Proficiency Test Program

MAT Proficiency Test Program

We offer quality assurance to laboratories working with Monocyte Activation Test (MAT). Based on our expertise we provide frequently audits of MAT test proficiency. Our Proficiency Test Program (PTP) confidentially verifies working procedures, method and report validation, identifies trends and potential demands for training. This supplies additional value to internal quality assurance.

 Benefits

  • Check and validate analysis techniques
  • Verify conformity of procedures to requirements of the Pharmacopoeia
  • Control and correct possible drift in procedural compliance
  • Verify laboratory’s ability to recover correct level of contamination
  • Compare results to those of other laboratories and other MAT methods
1 Step 1

MAT Proficiency Test Program (PTP) Request Form 2020
3rd PTP trial February 2020



Dear participants and interested parties,
 
The MAT PTP only works with your help, so despite the difficult times and limited operation, we decided to actively loosen the timelines for the MAT PTP, to react on the rising cases and widespread of COVID-19.

· Registration will be extended to the 17-July -2020 and samples will be sent to you accordingly.
· Provision of results will be extended approximately to the 01-August-2020.
· Distribution of final report will be extended approximately to 01-September-2020
 
These are only a preliminary dates, which will be further extended until every result will be handed in – we will keep you posted about the final date and the distribution of the reports.

Time Line


· Registration: 17.02.2020 to 17.06.2020
· Provision of results: approximately 01.08.2020
· Distribution of final report: approximately 01.09.2020

Note: You can find our complete data protection declaration in the menu item Privacy Policy. You can revoke your consent at any time for the future by email to: datenschutzbeauftragter@microcoat.de.

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MORE EVENTS
  • 04Mai

    Geschützt: ECA Monocyte Activation Test (MAT)

    Read More →
  • 28Apr

    Geschützt: ECA Low Endotoxin Recovery/Masking

    Read More →
  • 03Feb

    Meet us at the Pharmaceutical Microbiology East Coast conference – Boston, USA

    Read More →
  • 25Nov

    Low Endotoxin Recovery/Masking Training Course Munich/Bernried, GERMANY

    Read More →
  • 25Nov

    2nd Monocyte-Activation-Test proficiency test program, 13./14. Februar 2020

    Read More →
  • 21Okt

    Meet us at the PharmaLab 2019 Düsseldorf/Neuss, Germany

    Read More →
  • 23Sep

    Mikrobiologie-Konferenz, 01./02. Oktober 2019 – Mannheim

    Read More →
  • 18Sep

    2019 bioxchange workshop, Philadelphia PA | Philadelphia Downtown Hotel

    Read More →
  • 13Mai

    Meet us at the A3P, Lyon (5. – 6. June 2019)

    Read More →
  • 25Apr

    Meet us at the Workshop „Bioindicators“, Barcelona (07. May 2019)

    Read More →
READ MORE

Winner Pharmalab

Winner Pharmalab

And the winner of the One-Line-Drawing contest at PharmaLab 2019 is Limulus No. 32.

Please contact us at endotoxinservice@microcoat.de to get your JBL CHARGE 4 Bluetooth Speaker.

MORE EVENTS
  • 04Mai

    Geschützt: ECA Monocyte Activation Test (MAT)

    Read More →
  • 28Apr

    Geschützt: ECA Low Endotoxin Recovery/Masking

    Read More →
  • 03Feb

    Meet us at the Pharmaceutical Microbiology East Coast conference – Boston, USA

    Read More →
  • 25Nov

    Low Endotoxin Recovery/Masking Training Course Munich/Bernried, GERMANY

    Read More →
  • 25Nov

    2nd Monocyte-Activation-Test proficiency test program, 13./14. Februar 2020

    Read More →
  • 21Okt

    Meet us at the PharmaLab 2019 Düsseldorf/Neuss, Germany

    Read More →
  • 23Sep

    Mikrobiologie-Konferenz, 01./02. Oktober 2019 – Mannheim

    Read More →
  • 18Sep

    2019 bioxchange workshop, Philadelphia PA | Philadelphia Downtown Hotel

    Read More →
  • 13Mai

    Meet us at the A3P, Lyon (5. – 6. June 2019)

    Read More →
  • 25Apr

    Meet us at the Workshop „Bioindicators“, Barcelona (07. May 2019)

    Read More →
READ MORE

Create a Limulus with ONE-LINE-DRAWING to win a prize

Create a Limulus with ONE-LINE-DRAWING to win a prize

Win a JBL Charge 4 Bluetooth Speaker!

Create a Limulus with ONE LINE DRAWING.

Visit us at PharmaLab 2019 and take part in the competition to win the prize.

MORE EVENTS
  • 04Mai

    Geschützt: ECA Monocyte Activation Test (MAT)

    Read More →
  • 28Apr

    Geschützt: ECA Low Endotoxin Recovery/Masking

    Read More →
  • 03Feb

    Meet us at the Pharmaceutical Microbiology East Coast conference – Boston, USA

    Read More →
  • 25Nov

    Low Endotoxin Recovery/Masking Training Course Munich/Bernried, GERMANY

    Read More →
  • 25Nov

    2nd Monocyte-Activation-Test proficiency test program, 13./14. Februar 2020

    Read More →
  • 21Okt

    Meet us at the PharmaLab 2019 Düsseldorf/Neuss, Germany

    Read More →
  • 23Sep

    Mikrobiologie-Konferenz, 01./02. Oktober 2019 – Mannheim

    Read More →
  • 18Sep

    2019 bioxchange workshop, Philadelphia PA | Philadelphia Downtown Hotel

    Read More →
  • 13Mai

    Meet us at the A3P, Lyon (5. – 6. June 2019)

    Read More →
  • 25Apr

    Meet us at the Workshop „Bioindicators“, Barcelona (07. May 2019)

    Read More →
READ MORE

Microcoat announces the 2nd Monocyte-Activation Test Proficiency Test Program

Microcoat announces the 2nd Monocyte-Activation Test Proficiency Test Program

MAT Proficiency Test Program

We offer quality assurance to laboratories working with Monocyte Activation Test (MAT). Based on our expertise we provide frequently audits of MAT test proficiency. Our Proficiency Test Program (PTP) confidentially verifies working procedures, method and report validation, identifies trends and potential demands for training. This supplies additional value to internal quality assurance.

 Benefits

  • Check and validate analysis techniques
  • Verify conformity of procedures to requirements of the Pharmacopoeia
  • Control and correct possible drift in procedural compliance
  • Verify laboratory’s ability to recover correct level of contamination
  • Compare results to those of other laboratories and other MAT methods
MORE EVENTS
  • 04Mai

    Geschützt: ECA Monocyte Activation Test (MAT)

    Read More →
  • 28Apr

    Geschützt: ECA Low Endotoxin Recovery/Masking

    Read More →
  • 03Feb

    Meet us at the Pharmaceutical Microbiology East Coast conference – Boston, USA

    Read More →
  • 25Nov

    Low Endotoxin Recovery/Masking Training Course Munich/Bernried, GERMANY

    Read More →
  • 25Nov

    2nd Monocyte-Activation-Test proficiency test program, 13./14. Februar 2020

    Read More →
  • 21Okt

    Meet us at the PharmaLab 2019 Düsseldorf/Neuss, Germany

    Read More →
  • 23Sep

    Mikrobiologie-Konferenz, 01./02. Oktober 2019 – Mannheim

    Read More →
  • 18Sep

    2019 bioxchange workshop, Philadelphia PA | Philadelphia Downtown Hotel

    Read More →
  • 13Mai

    Meet us at the A3P, Lyon (5. – 6. June 2019)

    Read More →
  • 25Apr

    Meet us at the Workshop „Bioindicators“, Barcelona (07. May 2019)

    Read More →
READ MORE

Microcoat adds Quanterix´s SP-X to its portfolio of ultra-sensitive Immunoassays

Microcoat adds Quanterix´s SP-X to its portfolio of ultra-sensitive Immunoassays

We proudly announce that we have expanded our ultra-sensitive immunoassay portfolio by the brand-new Quanterix SP-X® Analyzer.

Once again, Microcoat is one of the first laboratories in Europe to offer an advanced new technology to their customers.

The Quanterix SP-X® Imaging and Analysis System is a complete benchtop system that offers true multiplex detection at both acute and baseline levels. Up to 10 parameters can be analyzed with superior sensitivity in this ECL based assay format with a low sample volume of only 25 µL. SP-X combines Simoa ultra-sensitive assay development and optimization with up to 10-plex multiplexing scale and flexibility to combine the analytes of interest.

The SP-X® completes our portfolio of biomarker assays especially in the fields of cytokine quantification, oncology and immune-oncology. Combined with our experience in immunoassay development, the platform enables the development of Simoa-sensitive planar assays meeting your individual requirements.

More than 55 commercial kits available at Quanterix ®.

For more information visit www.quanterix.com.

MORE EVENTS
  • 04Mai

    Geschützt: ECA Monocyte Activation Test (MAT)

    Read More →
  • 28Apr

    Geschützt: ECA Low Endotoxin Recovery/Masking

    Read More →
  • 03Feb

    Meet us at the Pharmaceutical Microbiology East Coast conference – Boston, USA

    Read More →
  • 25Nov

    Low Endotoxin Recovery/Masking Training Course Munich/Bernried, GERMANY

    Read More →
  • 25Nov

    2nd Monocyte-Activation-Test proficiency test program, 13./14. Februar 2020

    Read More →
  • 21Okt

    Meet us at the PharmaLab 2019 Düsseldorf/Neuss, Germany

    Read More →
  • 23Sep

    Mikrobiologie-Konferenz, 01./02. Oktober 2019 – Mannheim

    Read More →
  • 18Sep

    2019 bioxchange workshop, Philadelphia PA | Philadelphia Downtown Hotel

    Read More →
  • 13Mai

    Meet us at the A3P, Lyon (5. – 6. June 2019)

    Read More →
  • 25Apr

    Meet us at the Workshop „Bioindicators“, Barcelona (07. May 2019)

    Read More →
READ MORE

Technical Report No. 82 „Low Endotoxin Recovery“

Technical Report No. 82 „Low Endotoxin Recovery“

The PDA Technical Report No. 82 has been published in March 2019.

This report gives guidance on how to perform a Low Endotoxin Recovery (LER) study and shows mitigation strategies of endotoxin masking in biologics. Additionally the report is a good source of background information on bacterial endotoxin testing.

At Microcoat we perform LER studies based on the recommendation of the PDA Technical Report 82.

For more information click here: Service https://www.microcoat.de/laboratory-services/endotoxin-and-pyrogen-test-service-2/#Low-Endotoxin-Recovery-LER

Click here for the PDA Technical Report overview

MORE EVENTS
  • 04Mai

    Geschützt: ECA Monocyte Activation Test (MAT)

    Read More →
  • 28Apr

    Geschützt: ECA Low Endotoxin Recovery/Masking

    Read More →
  • 03Feb

    Meet us at the Pharmaceutical Microbiology East Coast conference – Boston, USA

    Read More →
  • 25Nov

    Low Endotoxin Recovery/Masking Training Course Munich/Bernried, GERMANY

    Read More →
  • 25Nov

    2nd Monocyte-Activation-Test proficiency test program, 13./14. Februar 2020

    Read More →
  • 21Okt

    Meet us at the PharmaLab 2019 Düsseldorf/Neuss, Germany

    Read More →
  • 23Sep

    Mikrobiologie-Konferenz, 01./02. Oktober 2019 – Mannheim

    Read More →
  • 18Sep

    2019 bioxchange workshop, Philadelphia PA | Philadelphia Downtown Hotel

    Read More →
  • 13Mai

    Meet us at the A3P, Lyon (5. – 6. June 2019)

    Read More →
  • 25Apr

    Meet us at the Workshop „Bioindicators“, Barcelona (07. May 2019)

    Read More →
READ MORE

Low Endotoxin Recovery – Masking of Naturally Occurring Endotoxin

Low Endotoxin Recovery – Masking of Naturally Occurring Endotoxin

Endotoxins are cell wall components of Gram-negative bacteria. A release of endotoxins into the human blood stream results in an inflammation reaction that can lead to life-threatening conditions like sepsis. Therefore, control for endotoxin contamination of intravenously administered drugs is crucial.

Drugs are usually tested for putative endotoxin contamination with Limulus-based tests. However, validity of the compendial test procedures is questioned in the case of low endotoxin recovery (LER).

To assure validity, regulatory authorities request hold-time studies of endotoxin in addition to pharmacopoeial requirements. Within these studies, endotoxin is added (spiked) to an undiluted product. The spiked product is held for a certain period of time and subsequently diluted for endotoxin determination. Due to the known heterogeneity of endotoxin the question has been raised as to which source represents the most adequate endotoxin spike.

In the present study, endotoxin hold-time studies were analyzed by using different sources of endotoxin. Highly purified endotoxin, crude endotoxin extracts (Naturally Occurring Endotoxin) from different bacterial species and varied growth conditions as well as endogenous endotoxin contaminations were investigated.

The results clearly demonstrate that endotoxin masking – an effect of LER – is dependent on the endotoxin source used. Various parameters such as bacterial strain and growth conditions lead to different masking susceptibilities. Due to these effects it is impossible to predict the susceptibility of bacterial endotoxin contamination to LER. In order to determine whether a sample is prone to LER, an endotoxin spike that is susceptible to LER is required.

MORE EVENTS
  • 04Mai

    Geschützt: ECA Monocyte Activation Test (MAT)

    Read More →
  • 28Apr

    Geschützt: ECA Low Endotoxin Recovery/Masking

    Read More →
  • 03Feb

    Meet us at the Pharmaceutical Microbiology East Coast conference – Boston, USA

    Read More →
  • 25Nov

    Low Endotoxin Recovery/Masking Training Course Munich/Bernried, GERMANY

    Read More →
  • 25Nov

    2nd Monocyte-Activation-Test proficiency test program, 13./14. Februar 2020

    Read More →
  • 21Okt

    Meet us at the PharmaLab 2019 Düsseldorf/Neuss, Germany

    Read More →
  • 23Sep

    Mikrobiologie-Konferenz, 01./02. Oktober 2019 – Mannheim

    Read More →
  • 18Sep

    2019 bioxchange workshop, Philadelphia PA | Philadelphia Downtown Hotel

    Read More →
  • 13Mai

    Meet us at the A3P, Lyon (5. – 6. June 2019)

    Read More →
  • 25Apr

    Meet us at the Workshop „Bioindicators“, Barcelona (07. May 2019)

    Read More →
READ MORE