Skip to Content

Category Archives: Microcoat News

And the winner of the BOSE Headphones is…

And the winner of the BOSE Headphones is…

And the winner of the BOSE Headphones is Limulus No. 7

Please contact us at to get your price!

MORE EVENTS
  • 21Sep

    Meet us at the PharmaLab 2018 Düsseldorf/Neuss, Germany

    Read More →
  • 25Mai

    Meet us at the Lonza Endotoxin Summit, (12. – 14. June 2018)

    Read More →
  • 25Mai

    Participation to job exchange at the Hochschule Biberach HBC

    Read More →
  • 27Feb

    Low Endotoxin Recovery/Masking Training Munich/Bernried, Germany

    Read More →
  • 02Nov

    Visit us at our booth at the Munich Biomarker Conference 2016

    Read More →
  • 02Nov

    Meet us at the Pharmalab 2016

    Read More →
  • 08Apr

    Meet us at the Analytica 2016

    Read More →
  • 27Nov

    Meet us at the 5th Annual Outsourcing in Clinical Trials Europe

    Read More →
  • 27Nov

    Microcoat participates the PDA Europe 2015

    Read More →
READ MORE

Create your own Horseshoe Crab!

Create your own Horseshoe Crab!

Win a noise cancelling head phone from BOSE!

Visit our booth at PharmaLab from 20th to 21st of November and create your own Crab out of playdough.

MORE EVENTS
  • 21Sep

    Meet us at the PharmaLab 2018 Düsseldorf/Neuss, Germany

    Read More →
  • 25Mai

    Meet us at the Lonza Endotoxin Summit, (12. – 14. June 2018)

    Read More →
  • 25Mai

    Participation to job exchange at the Hochschule Biberach HBC

    Read More →
  • 27Feb

    Low Endotoxin Recovery/Masking Training Munich/Bernried, Germany

    Read More →
  • 02Nov

    Visit us at our booth at the Munich Biomarker Conference 2016

    Read More →
  • 02Nov

    Meet us at the Pharmalab 2016

    Read More →
  • 08Apr

    Meet us at the Analytica 2016

    Read More →
  • 27Nov

    Meet us at the 5th Annual Outsourcing in Clinical Trials Europe

    Read More →
  • 27Nov

    Microcoat participates the PDA Europe 2015

    Read More →
READ MORE

The Endotoxin-Service announces the succesful participation on the LAL PTP study B18

The Endotoxin-Service announces the succesful participation on the LAL PTP study B18

The Endotoxin-Service announces the successful participation on the LAL PTP study B18.

With this result we can look back on 5 years of successful LAL PTP studies.

MORE EVENTS
  • 21Sep

    Meet us at the PharmaLab 2018 Düsseldorf/Neuss, Germany

    Read More →
  • 25Mai

    Meet us at the Lonza Endotoxin Summit, (12. – 14. June 2018)

    Read More →
  • 25Mai

    Participation to job exchange at the Hochschule Biberach HBC

    Read More →
  • 27Feb

    Low Endotoxin Recovery/Masking Training Munich/Bernried, Germany

    Read More →
  • 02Nov

    Visit us at our booth at the Munich Biomarker Conference 2016

    Read More →
  • 02Nov

    Meet us at the Pharmalab 2016

    Read More →
  • 08Apr

    Meet us at the Analytica 2016

    Read More →
  • 27Nov

    Meet us at the 5th Annual Outsourcing in Clinical Trials Europe

    Read More →
  • 27Nov

    Microcoat participates the PDA Europe 2015

    Read More →
READ MORE

Meet us at the PharmaLab 2018 Düsseldorf/Neuss, Germany

Meet us at the PharmaLab 2018 Düsseldorf/Neuss, Germany

PharmaLab

Düsseldorf/Neuss, Germany

20 – 21. November 2018

https://www.pharmalab-kongress.de/

MORE EVENTS
  • 21Sep

    Meet us at the PharmaLab 2018 Düsseldorf/Neuss, Germany

    Read More →
  • 25Mai

    Meet us at the Lonza Endotoxin Summit, (12. – 14. June 2018)

    Read More →
  • 25Mai

    Participation to job exchange at the Hochschule Biberach HBC

    Read More →
  • 27Feb

    Low Endotoxin Recovery/Masking Training Munich/Bernried, Germany

    Read More →
  • 02Nov

    Visit us at our booth at the Munich Biomarker Conference 2016

    Read More →
  • 02Nov

    Meet us at the Pharmalab 2016

    Read More →
  • 08Apr

    Meet us at the Analytica 2016

    Read More →
  • 27Nov

    Meet us at the 5th Annual Outsourcing in Clinical Trials Europe

    Read More →
  • 27Nov

    Microcoat participates the PDA Europe 2015

    Read More →
READ MORE

We now offer affordable ultra-sensitive biomarker detection with Simoa™ technology

We now offer affordable ultra-sensitive biomarker detection with Simoa™ technology

We are proud to announce that we now offer an exciting immunoassay platform to our customers that opens up new horizons in biomarker analysis. As one of the very first in Europe we have introduced the benchtop Simoa™ Quanterix SR-X™ Biomarker Detection System.

Simoa™ is a single molecule digital detection technology that represents a platform for multiplexed detection of up to 6 biomarkers per sample. It provides ultra-sensitive detection capabilities, while it remains just as affordable as a regular ELISA assay. Additionally, low volume requirements conserve precious samples. The SR-X™ traps and isolates individual immunocomplexes on paramagnetic beads in thousands of femtoliter-sized wells on a disposable disc. Only one single molecule is needed to obtain a suitable fluorescence signal.

Not only does Quanterix offer over 70 commercially available Simoa kits, the SR-X™ also enables fast assay development tailored to our customers’ demands for both circulating proteins and nucleic acids from blood, without complex pre-analytical extraction and PCR. Customers can rely on our extensive expertise in the development of bead-based assays.

Thus, no matter whether you desire exploratory routine sample measurements or seek to develop novel assays of great efficiency, we can offer the implementation of a vast variety of large molecule assays on Simoa™ technology. The SR-X™ enables us to detect biomarkers with an unparalleled sensitivity, 1000x higher than standard immunoassay methods with high precision across a range of sample types and according to highest quality standards.

MORE EVENTS
  • 21Sep

    Meet us at the PharmaLab 2018 Düsseldorf/Neuss, Germany

    Read More →
  • 25Mai

    Meet us at the Lonza Endotoxin Summit, (12. – 14. June 2018)

    Read More →
  • 25Mai

    Participation to job exchange at the Hochschule Biberach HBC

    Read More →
  • 27Feb

    Low Endotoxin Recovery/Masking Training Munich/Bernried, Germany

    Read More →
  • 02Nov

    Visit us at our booth at the Munich Biomarker Conference 2016

    Read More →
  • 02Nov

    Meet us at the Pharmalab 2016

    Read More →
  • 08Apr

    Meet us at the Analytica 2016

    Read More →
  • 27Nov

    Meet us at the 5th Annual Outsourcing in Clinical Trials Europe

    Read More →
  • 27Nov

    Microcoat participates the PDA Europe 2015

    Read More →
READ MORE

Investigation of the kinetics and mechanism of low endotoxin recovery

Investigation of the kinetics and mechanism of low endotoxin recovery

The inability to detect endotoxin added to undiluted drug samples has been called: Low Endotoxin Recovery (LER). The phenomenon has caused concerns amongst drug manufacturing quality control scientists in that manufactured solutions contaminated with endotoxin could show false-negative results via routine Limulus-based tests.

The time-dependent appearance of LER has been analyzed in detail to provide a better understanding of the mechanism. The assumption has been that the root-cause of LER involves the interplay of endotoxin with surfactants and results in aggregate structures that are complexed with surfactants. The endotoxin molecules when complexed with surfactants are not accessible for Limulus-based detection.

The results demonstrate a predominant role of complex-forming agents. It was shown that although the presence of surfactants is a strong prerequisite for masking, it does not determine the kinetics of endotoxin masking. Interestingly, the endotoxin concentration itself had no substantial impact on LER kinetics. By adjusting the ratios of complex-forming constituents, including surfactant, chelator and endotoxin, and by testing the order in which the constituents are added, a new model for simulating masking kinetics has been determined. Our work provides for the first time a model to simulate masking kinetics of endotoxin which lends a better understanding of LER

MORE EVENTS
  • 21Sep

    Meet us at the PharmaLab 2018 Düsseldorf/Neuss, Germany

    Read More →
  • 25Mai

    Meet us at the Lonza Endotoxin Summit, (12. – 14. June 2018)

    Read More →
  • 25Mai

    Participation to job exchange at the Hochschule Biberach HBC

    Read More →
  • 27Feb

    Low Endotoxin Recovery/Masking Training Munich/Bernried, Germany

    Read More →
  • 02Nov

    Visit us at our booth at the Munich Biomarker Conference 2016

    Read More →
  • 02Nov

    Meet us at the Pharmalab 2016

    Read More →
  • 08Apr

    Meet us at the Analytica 2016

    Read More →
  • 27Nov

    Meet us at the 5th Annual Outsourcing in Clinical Trials Europe

    Read More →
  • 27Nov

    Microcoat participates the PDA Europe 2015

    Read More →
READ MORE

The changing environment in pyrogen and endotoxin testing

MORE NEWS
  • 06Dez

    And the winner of the BOSE Headphones is…

    Read More →
  • 09Nov

    Create your own Horseshoe Crab!

    Read More →
  • 02Okt

    The Endotoxin-Service announces the succesful participation on the LAL PTP study B18

    Read More →
  • 21Sep

    Meet us at the PharmaLab 2018 Düsseldorf/Neuss, Germany

    Read More →
  • 25Mai

    Meet us at the Lonza Endotoxin Summit, (12. – 14. June 2018)

    Read More →
  • 25Mai

    Participation to job exchange at the Hochschule Biberach HBC

    Read More →
  • 23Mai

    We now offer affordable ultra-sensitive biomarker detection with Simoa™ technology

    Read More →
  • 23Mai

    Investigation of the kinetics and mechanism of low endotoxin recovery

    Read More →
  • 04Mai

    The changing environment in pyrogen and endotoxin testing

    Read More →
  • 27Feb

    Low Endotoxin Recovery/Masking Training Munich/Bernried, Germany

    Read More →
READ MORE

pLDH recombinant panels for malaria diagnostic tests

pLDH recombinant panels for malaria diagnostic tests

Press release: pLDH recombinant panels for malaria diagnostic tests

Microcoat and the Foundation for Innovative New Diagnostics (FIND) announce the launch of pLDH recombinant panels for assessment of the malaria rapid diagnostic test performance in product evaluation and lot testing programs.

Read the full press release here:

Microcoat-FIND_press release_launch rec panels

Find out more about the products here.

MORE NEWS
  • 06Dez

    And the winner of the BOSE Headphones is…

    Read More →
  • 09Nov

    Create your own Horseshoe Crab!

    Read More →
  • 02Okt

    The Endotoxin-Service announces the succesful participation on the LAL PTP study B18

    Read More →
  • 21Sep

    Meet us at the PharmaLab 2018 Düsseldorf/Neuss, Germany

    Read More →
  • 25Mai

    Meet us at the Lonza Endotoxin Summit, (12. – 14. June 2018)

    Read More →
  • 25Mai

    Participation to job exchange at the Hochschule Biberach HBC

    Read More →
  • 23Mai

    We now offer affordable ultra-sensitive biomarker detection with Simoa™ technology

    Read More →
  • 23Mai

    Investigation of the kinetics and mechanism of low endotoxin recovery

    Read More →
  • 04Mai

    The changing environment in pyrogen and endotoxin testing

    Read More →
  • 27Feb

    Low Endotoxin Recovery/Masking Training Munich/Bernried, Germany

    Read More →
READ MORE

Press release: HRP2 recombinant panel now available for malaria rapid diagnostic tests

Press release: HRP2 recombinant panel now available for malaria rapid diagnostic tests

Press release: HRP2 recombinant panel now available for malaria rapid diagnostic tests

Microcoat and the Foundation for Innovative New Diagnostics (FIND) announce the launch of HRP2 recombinant panel for assessment of the malaria rapid diagnostic test performance in product evaluation and lot testing programs

Read the full press release here:

Microcoat-FIND_press release_04.09.2017-final

MORE NEWS
  • 06Dez

    And the winner of the BOSE Headphones is…

    Read More →
  • 09Nov

    Create your own Horseshoe Crab!

    Read More →
  • 02Okt

    The Endotoxin-Service announces the succesful participation on the LAL PTP study B18

    Read More →
  • 21Sep

    Meet us at the PharmaLab 2018 Düsseldorf/Neuss, Germany

    Read More →
  • 25Mai

    Meet us at the Lonza Endotoxin Summit, (12. – 14. June 2018)

    Read More →
  • 25Mai

    Participation to job exchange at the Hochschule Biberach HBC

    Read More →
  • 23Mai

    We now offer affordable ultra-sensitive biomarker detection with Simoa™ technology

    Read More →
  • 23Mai

    Investigation of the kinetics and mechanism of low endotoxin recovery

    Read More →
  • 04Mai

    The changing environment in pyrogen and endotoxin testing

    Read More →
  • 27Feb

    Low Endotoxin Recovery/Masking Training Munich/Bernried, Germany

    Read More →
READ MORE

Microcoat now offering Assay Development and Sample Measurement on MSD® Platform

Microcoat now offering Assay Development and Sample Measurement on MSD® Platform

Microcoat expands its technological portfolio by Meso Scale Discovery´s Electrochemiluminescence (MSD-ECL) platform. Based on non-radioactive electrochemiluminescent labels for ultra-sensitive detection, MSD yields higher sensitivity and broader dynamic range compared to ELISA technology. Microcoat offers development of assays from the scratch as well as transfer of classical ELISA formats in addition to method comparison, validation and sample measurement.  Customers profit from our year-long experience in custom-fit optimization and manufacturing of antibody conjugates including MSD´s SULFO-Tag®.

MORE NEWS
  • 06Dez

    And the winner of the BOSE Headphones is…

    Read More →
  • 09Nov

    Create your own Horseshoe Crab!

    Read More →
  • 02Okt

    The Endotoxin-Service announces the succesful participation on the LAL PTP study B18

    Read More →
  • 21Sep

    Meet us at the PharmaLab 2018 Düsseldorf/Neuss, Germany

    Read More →
  • 25Mai

    Meet us at the Lonza Endotoxin Summit, (12. – 14. June 2018)

    Read More →
  • 25Mai

    Participation to job exchange at the Hochschule Biberach HBC

    Read More →
  • 23Mai

    We now offer affordable ultra-sensitive biomarker detection with Simoa™ technology

    Read More →
  • 23Mai

    Investigation of the kinetics and mechanism of low endotoxin recovery

    Read More →
  • 04Mai

    The changing environment in pyrogen and endotoxin testing

    Read More →
  • 27Feb

    Low Endotoxin Recovery/Masking Training Munich/Bernried, Germany

    Read More →
READ MORE