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Category Archives: Microcoat News

Create your own Horseshoe Crab!

Create your own Horseshoe Crab!

Win a noise cancelling head phone from BOSE!

Visit our booth at PharmaLab from 20th to 21st of November and create your own Crab out of playdough.

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  • 07Okt

    Job- und Ausbildungsmesse 14.10.2021 11:00 Uhr bis 21:00 Uhr in der Tiefenstollenhalle Peißenberg

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  • 29Sep

    Job- und Ausbildungsmesse 05.10.2021 11:30 Uhr bis 21:00 Uhr in der Stadthalle Penzberg

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  • 14Mai

    Digitale Jobmesse 2021 der Hochschule Biberach

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  • 04Mai

    Geschützt: ECA Monocyte Activation Test (MAT)

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  • 28Apr

    Geschützt: ECA Low Endotoxin Recovery/Masking

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  • 03Feb

    Meet us at the Pharmaceutical Microbiology East Coast conference – Boston, USA

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  • 25Nov

    Low Endotoxin Recovery/Masking Training Course Munich/Bernried, GERMANY

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  • 25Nov

    2nd Monocyte-Activation-Test proficiency test program, 13./14. Februar 2020

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  • 21Okt

    Meet us at the PharmaLab 2019 Düsseldorf/Neuss, Germany

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  • 23Sep

    Mikrobiologie-Konferenz, 01./02. Oktober 2019 – Mannheim

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The Endotoxin-Service announces the succesful participation on the LAL PTP study B18

The Endotoxin-Service announces the succesful participation on the LAL PTP study B18

The Endotoxin-Service announces the successful participation on the LAL PTP study B18.

With this result we can look back on 5 years of successful LAL PTP studies.

MORE EVENTS
  • 07Okt

    Job- und Ausbildungsmesse 14.10.2021 11:00 Uhr bis 21:00 Uhr in der Tiefenstollenhalle Peißenberg

    Read More →
  • 29Sep

    Job- und Ausbildungsmesse 05.10.2021 11:30 Uhr bis 21:00 Uhr in der Stadthalle Penzberg

    Read More →
  • 14Mai

    Digitale Jobmesse 2021 der Hochschule Biberach

    Read More →
  • 04Mai

    Geschützt: ECA Monocyte Activation Test (MAT)

    Read More →
  • 28Apr

    Geschützt: ECA Low Endotoxin Recovery/Masking

    Read More →
  • 03Feb

    Meet us at the Pharmaceutical Microbiology East Coast conference – Boston, USA

    Read More →
  • 25Nov

    Low Endotoxin Recovery/Masking Training Course Munich/Bernried, GERMANY

    Read More →
  • 25Nov

    2nd Monocyte-Activation-Test proficiency test program, 13./14. Februar 2020

    Read More →
  • 21Okt

    Meet us at the PharmaLab 2019 Düsseldorf/Neuss, Germany

    Read More →
  • 23Sep

    Mikrobiologie-Konferenz, 01./02. Oktober 2019 – Mannheim

    Read More →
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Meet us at the PharmaLab 2018 Düsseldorf/Neuss, Germany

Meet us at the PharmaLab 2018 Düsseldorf/Neuss, Germany

PharmaLab

Düsseldorf/Neuss, Germany

20 – 21. November 2018

https://www.pharmalab-kongress.de/

MORE EVENTS
  • 07Okt

    Job- und Ausbildungsmesse 14.10.2021 11:00 Uhr bis 21:00 Uhr in der Tiefenstollenhalle Peißenberg

    Read More →
  • 29Sep

    Job- und Ausbildungsmesse 05.10.2021 11:30 Uhr bis 21:00 Uhr in der Stadthalle Penzberg

    Read More →
  • 14Mai

    Digitale Jobmesse 2021 der Hochschule Biberach

    Read More →
  • 04Mai

    Geschützt: ECA Monocyte Activation Test (MAT)

    Read More →
  • 28Apr

    Geschützt: ECA Low Endotoxin Recovery/Masking

    Read More →
  • 03Feb

    Meet us at the Pharmaceutical Microbiology East Coast conference – Boston, USA

    Read More →
  • 25Nov

    Low Endotoxin Recovery/Masking Training Course Munich/Bernried, GERMANY

    Read More →
  • 25Nov

    2nd Monocyte-Activation-Test proficiency test program, 13./14. Februar 2020

    Read More →
  • 21Okt

    Meet us at the PharmaLab 2019 Düsseldorf/Neuss, Germany

    Read More →
  • 23Sep

    Mikrobiologie-Konferenz, 01./02. Oktober 2019 – Mannheim

    Read More →
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We now offer affordable ultra-sensitive biomarker detection with Simoa™ technology

We now offer affordable ultra-sensitive biomarker detection with Simoa™ technology

We are proud to announce that we now offer an exciting immunoassay platform to our customers that opens up new horizons in biomarker analysis. As one of the very first in Europe we have introduced the benchtop Simoa™ Quanterix SR-X™ Biomarker Detection System.

Simoa™ is a single molecule digital detection technology that represents a platform for multiplexed detection of up to 6 biomarkers per sample. It provides ultra-sensitive detection capabilities, while it remains just as affordable as a regular ELISA assay. Additionally, low volume requirements conserve precious samples. The SR-X™ traps and isolates individual immunocomplexes on paramagnetic beads in thousands of femtoliter-sized wells on a disposable disc. Only one single molecule is needed to obtain a suitable fluorescence signal.

Not only does Quanterix offer over 70 commercially available Simoa kits, the SR-X™ also enables fast assay development tailored to our customers’ demands for both circulating proteins and nucleic acids from blood, without complex pre-analytical extraction and PCR. Customers can rely on our extensive expertise in the development of bead-based assays.

Thus, no matter whether you desire exploratory routine sample measurements or seek to develop novel assays of great efficiency, we can offer the implementation of a vast variety of large molecule assays on Simoa™ technology. The SR-X™ enables us to detect biomarkers with an unparalleled sensitivity, 1000x higher than standard immunoassay methods with high precision across a range of sample types and according to highest quality standards.

MORE EVENTS
  • 07Okt

    Job- und Ausbildungsmesse 14.10.2021 11:00 Uhr bis 21:00 Uhr in der Tiefenstollenhalle Peißenberg

    Read More →
  • 29Sep

    Job- und Ausbildungsmesse 05.10.2021 11:30 Uhr bis 21:00 Uhr in der Stadthalle Penzberg

    Read More →
  • 14Mai

    Digitale Jobmesse 2021 der Hochschule Biberach

    Read More →
  • 04Mai

    Geschützt: ECA Monocyte Activation Test (MAT)

    Read More →
  • 28Apr

    Geschützt: ECA Low Endotoxin Recovery/Masking

    Read More →
  • 03Feb

    Meet us at the Pharmaceutical Microbiology East Coast conference – Boston, USA

    Read More →
  • 25Nov

    Low Endotoxin Recovery/Masking Training Course Munich/Bernried, GERMANY

    Read More →
  • 25Nov

    2nd Monocyte-Activation-Test proficiency test program, 13./14. Februar 2020

    Read More →
  • 21Okt

    Meet us at the PharmaLab 2019 Düsseldorf/Neuss, Germany

    Read More →
  • 23Sep

    Mikrobiologie-Konferenz, 01./02. Oktober 2019 – Mannheim

    Read More →
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Investigation of the kinetics and mechanism of low endotoxin recovery

Investigation of the kinetics and mechanism of low endotoxin recovery

The inability to detect endotoxin added to undiluted drug samples has been called: Low Endotoxin Recovery (LER). The phenomenon has caused concerns amongst drug manufacturing quality control scientists in that manufactured solutions contaminated with endotoxin could show false-negative results via routine Limulus-based tests.

The time-dependent appearance of LER has been analyzed in detail to provide a better understanding of the mechanism. The assumption has been that the root-cause of LER involves the interplay of endotoxin with surfactants and results in aggregate structures that are complexed with surfactants. The endotoxin molecules when complexed with surfactants are not accessible for Limulus-based detection.

The results demonstrate a predominant role of complex-forming agents. It was shown that although the presence of surfactants is a strong prerequisite for masking, it does not determine the kinetics of endotoxin masking. Interestingly, the endotoxin concentration itself had no substantial impact on LER kinetics. By adjusting the ratios of complex-forming constituents, including surfactant, chelator and endotoxin, and by testing the order in which the constituents are added, a new model for simulating masking kinetics has been determined. Our work provides for the first time a model to simulate masking kinetics of endotoxin which lends a better understanding of LER

MORE EVENTS
  • 07Okt

    Job- und Ausbildungsmesse 14.10.2021 11:00 Uhr bis 21:00 Uhr in der Tiefenstollenhalle Peißenberg

    Read More →
  • 29Sep

    Job- und Ausbildungsmesse 05.10.2021 11:30 Uhr bis 21:00 Uhr in der Stadthalle Penzberg

    Read More →
  • 14Mai

    Digitale Jobmesse 2021 der Hochschule Biberach

    Read More →
  • 04Mai

    Geschützt: ECA Monocyte Activation Test (MAT)

    Read More →
  • 28Apr

    Geschützt: ECA Low Endotoxin Recovery/Masking

    Read More →
  • 03Feb

    Meet us at the Pharmaceutical Microbiology East Coast conference – Boston, USA

    Read More →
  • 25Nov

    Low Endotoxin Recovery/Masking Training Course Munich/Bernried, GERMANY

    Read More →
  • 25Nov

    2nd Monocyte-Activation-Test proficiency test program, 13./14. Februar 2020

    Read More →
  • 21Okt

    Meet us at the PharmaLab 2019 Düsseldorf/Neuss, Germany

    Read More →
  • 23Sep

    Mikrobiologie-Konferenz, 01./02. Oktober 2019 – Mannheim

    Read More →
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The changing environment in pyrogen and endotoxin testing

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Press release: HRP2 recombinant panel now available for malaria rapid diagnostic tests

Press release: HRP2 recombinant panel now available for malaria rapid diagnostic tests

Press release: HRP2 recombinant panel now available for malaria rapid diagnostic tests

Microcoat and the Foundation for Innovative New Diagnostics (FIND) announce the launch of HRP2 recombinant panel for assessment of the malaria rapid diagnostic test performance in product evaluation and lot testing programs

Read the full press release here:

Microcoat-FIND_press release_04.09.2017-final

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Microcoat now offering Assay Development and Sample Measurement on MSD® Platform

Microcoat now offering Assay Development and Sample Measurement on MSD® Platform

Microcoat expands its technological portfolio by Meso Scale Discovery´s Electrochemiluminescence (MSD-ECL) platform. Based on non-radioactive electrochemiluminescent labels for ultra-sensitive detection, MSD yields higher sensitivity and broader dynamic range compared to ELISA technology. Microcoat offers development of assays from the scratch as well as transfer of classical ELISA formats in addition to method comparison, validation and sample measurement.  Customers profit from our year-long experience in custom-fit optimization and manufacturing of antibody conjugates including MSD´s SULFO-Tag®.

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Microcoat announces the launch of WATSON bioanalytical LIMS

Microcoat announces the launch of WATSON bioanalytical LIMS

Microcoat´s Laboratory Services announces launch of Thermo Scientific™ Watson™ bioanalytical LIMS V. 7.5

For clinical and pre-clinical drug development support, the right LIMS can accelerate sample turnaround, improve operational efficiency and drive quality and compliance.

Microcoat selected Thermo Scientific™ Watson LIMS™, a bioanalytical LIMS installed in 18 of the top 20 global pharmaceutical organizations and widely used in leading biotechnology and contract research organizations worldwide. Watson LIMS™ facilitates efficient study design and data transfer while streamlining assay validation, bioanalysis, instrument interfacing, sample tracking, results reporting and regulatory compliance.

With Watson LIMS™ Version 7.5 we obtained the latest version which also supports assay validation studies. The system is fully validated to meet all relevant requirements for the support of regulated PK and Immunogenicity studies.

All sample management activities will be transferred from existing systems into Watson LIMS to ensure full traceability from sample reception through analysis to long-term storage. Starting from the implementation of microplate readers, we subsequently plan to integrate more technology platforms (MSD©, Cobas©, ELLA©) to further improve and streamline our workflows.

Thermo Scientific™ Watson LIMS™ software is specifically designed and built to support the bioanalytical workflow, allowing to:

  • Manage both small and large molecule workflows in a single solution
  • Harmonize laboratory processes across all sites
  • Ease exchange of information between sponsors and contract labs
  • Increase throughput by automating data handling and reporting tasks
  • Promote compliance throughout the workflow
  • Implement quantitative concentration assays or qualitative immunogenicity assays
  • Track study sample history from receipt to disposal
  • Comply with SOPs and reduce the risk of non-compliance” (www.thermofisher.com)
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Press release: Positive control wells now available for rapid on-site quality assurance of Malaria rapid tests

Press release: Positive control wells now available for rapid on-site quality assurance of Malaria rapid tests

Microcoat and the Foundation for Innovative New Diagnostics (FIND) announce the launch of Positive Control Wells for rapid on-site quality assurance of Malaria Rapid Tests.

Read the full press release here:

MC_FIND press release

For more information please read also the following factsheets:

Positive control wells for malaria rapid diagnostic tests – Pilot introduction in Kenya & Tanzania – http://www.finddx.org/wp-content/uploads/2016/09/MALARIA-PCW-pilot-introduction-Summary-29Sep2016.pdf

Positive control wells for quality assurance of malaria RDTs at point of use – http://www.finddx.org/wp-content/uploads/2016/01/20160316_PCW-Factsheet_FINAL.pdf

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